Can “take off” be used in the imperative like “clear off” “go away” “piss off”?

I want to say yes, but I have this nagging fear it's Canadian English only ...

If you Canadian, yes.

I’d know what you mean but I’ve never heard it before

American West coast here - I don't think I've ever heard it used like those would be.

It's a *Canadian* way of saying "get lost". Example: The song "Take Off" by Canadian comedians Bob & Doug McKenzie (real names: Rick Moranis and [Dave Thomas](https://en.wikipedia.org/wiki/Dave_Thomas_(actor))) and legendary rock vocalist/singer Geddy Lee: [https://www.youtube.com/watch?v=QL0120iJhrA](https://www.youtube.com/watch?v=QL0120iJhrA) The song is full of Canadian slang--"take off", "hoser", "beauty way", etc.

I would definitely cause a bit of confusion if context is lacking but otherwise it should be perfectly fine.

I've never heard such a usage

I love this question. TIL that Canadians say "take off" as an imperative. Fascinating. To add one more vote into the mix, I'm in the US and I've never heard or said this as an imperative.